This is a detailed, evidence-based review of the 14 most popular weight loss pills and supplements on the market today.
There are many possible weight loss solutions out there.
Some options are more popular than others, including certain pills, drugs, and natural supplements. These claim to help you lose weight, or at least to make it easier to lose weight when you combine them with other methods.
They tend to work via one or more of these mechanisms:
Reducing appetite, making you feel more full so that you eat fewer calories
Reducing the absorption of nutrients such as fat, making you take in fewer calories
Increasing fat burning, making you burn more calories
boosting your metabolism
It’s important to consider that You should always discuss any diet or supplement changes with a doctor or registered dietitian.
To separate the myths from facts, here are the 14 most popular weight loss pills and supplements, reviewed by science.
If you're interested in using any of the introduced products, you can visit and buy from their official website through the official website button.
Weight loss pills and supplements
1. Alpilean
Alpilean became popular worldwide In 2022 after a scientific discovery at Stanford University School of Medicine about a common factor in overweight women and men, low inner body temperature.
How it works: it claims to use a proprietary blend of 6 alpine nutrients and plants designed to target and optimize low inner body temperature, a new cause of unexplained weight gain.
Side effects: Alpilean is a natural proprietary formula manufactured in the USA at FDA registered and GMP-certified facility using state-of-the-art, precision-engineered machinery and under the strictest and most sterile standards.
but As always we advise you to show a bottle of this to your doctor before you take it, just to be safe.
SUMMARY
Since there haven't been any reports of any damaging side effects while using Alpilean and it claims to be no Stimulants and non-habit Forming, it seems a worthwhile product to try to help you lose weight.
Lean Belly 3X is produced by Beyond 40 which is the company behind many supplements, started by Shaun and Karen Hadsall. As the name implies their products often supply people over forty and Lean Belly 3X is their forerunner and best seller product.
How it works: The company acknowledges that the Lean Belly 3X supplement works from a different angle, using only two active ingredients, safflower oil, and black pepper extract. Each portion contains 1,500 mg safflower oil, plus 5 mg black pepper extract. Lean Belly 3X’s safflower oil contains “Conjugated Linoleic Acid (CLA)”, a type of fatty acid that actively works in fat-burning.
A lot of dietary companies have discovered CLA and taken advantage of its benefits. In the 1970s, some researchers successfully isolated this linoleic acid and found its obvious effects on biological activities. its positive weight loss results are very promising. For example, lipoprotein lipase, a fat-storing enzyme, is found on every cell’s surface, and its activity increases after age 40. Studies have shown that Lean Belly 3X can prevent this agent. It converts stored fat to triglycerides, which then convert into energy.
Side effects: Multiple studies have confirmed consuming CLA daily can be beneficial in fat loss in various ways. Furthermore, generally recognized as safe (GRAS) by the FDA, companies can make use of CLA in supplement manufacturing.
SUMMARY
Lean Belly 3X is known as one of the most studied toning supplements and plenty of research proved its positive effect on shedding weight around the belly.
Sleep Slim Tea is a weight loss tea that contains a blend of ingredients that are said to help with weight loss.
How it works: The company behind Sleep Slim Tea says that the tea can help you lose weight by boosting your metabolism and suppressing your appetite.
Some of its ingredients like Magnolia bark, Ginger root powder, Cinnamon bark extract, and Calcium have a reliable scientific background that can reduce body weight and body fat, increase metabolism and regulate blood pressure. In general, none of the ingredients have been proven to be harmful.
Side effects: The weight loss formula is also FDA-approved and formulated in a GMP-certified facility. It is claimed to be 100% natural and does not have any side effects as per the manufacturers. There are no known side effects of Sleep Slim Tea also known as PureLife.
Refund Policy: 60 Days Money Back Guarantee
SUMMARY
Sleep Slim Tea is made from all-natural ingredients and is considered safe for most people. However, as with any supplement, it’s always best to speak to a healthcare professional before taking it.
4. PROTETOX
Protetox is a supplement and natural weight loss formula that helps detoxify the body by enhancing thermogenesis and fat oxidation. Every Protetox capsule contains several famous medicinal herbs, minerals, vitamins, and other nutrients.
How it works: Protetox contains a concentrated formula of powerful natural antioxidants scientifically designed to detoxify and support weight loss.
Protetox detoxifying ingredients get rid of impurities in the system and work as a cleansing regimen. Eliminating these components is the way to achieve weight loss because they’re the primary cause of obesity and accumulating fats.
Protetox claims to supercharge your metabolic rate and balance your hormonal levels to the point to lead your body to torch extra fat. It works like a hardcore vegetarian diet riched in vegetables and fruits. It fights against the leading cause of obesity and quickly promotes the fat-torching process without hassles.
Side effects: Most ingredients in this precisely calculated blend have roots in traditional or modern medicine or both. Medically proven or popularly believed to be effective.
SUMMARY
Since it is an Antibiotic Free, Gluten Free, NON-GMO, Manufactured in an FDA Registered Facility, and also its proprietary formula contains some of the most protective natural superfoods it seems a worthwhile supplement to help you in the weight loss process.
5. PT Trim
PT Trim Fat Burn is a weight loss supplement that contains purple tea as its main ingredient. This supplement claims to use the power of purple tea to help boost your metabolism and burn fat.
How it works: PT Trim Fat Burn is taken as a pill supplement. The recommended dosage is two pills per day, taken with water before meals.
Purple tea in PT Trim Fat Burn is rich in polyphenols, also Purple tea is rich in antioxidants and has been shown to boost metabolism and promote fat loss in several studies. Additionally, purple tea is a good source of fiber, which can help to keep you feeling full and promote weight loss.
Side effects: PT Trim Fat Burn is made with all-natural ingredients and is considered to be safe for most adults. It’s important to note that the purple tea in this supplement is decaffeinated, so you won’t have to worry about any unwanted side effects such as jitters or insomnia. However, as with any supplement, it’s always best to speak with your doctor before taking PT Trim Fat Burn, especially if you have any underlying health conditions.
SUMMARY
There is currently no human research on the weight loss effects of purple tea. However, animal research is very promising.
LeanBiome is a dietary supplement with a probiotic structure that helps with bacteria balance in the body. As it claims, with a dose of beneficial bacteria, you can reduce the negative effect of harmful bacteria on the body’s metabolism. This new product has shown tremendous results in losing weight.
How it works: LeanBiome's unique and proprietary formula is the first in the world to combine nine clinically-researched 'lean bacteria' species with Greenselect Phytosome, a next-generation and caffeine-free green tea extract formulated with patented, absorption-boosting Phytosome technology.
Together, this advanced ingredient blend helps to quickly reverse the bacterial imbalance in your gut microbiome – the newly-discovered root cause of belly fat and unexplained weight gain.
LeanBiome helps the body keep its guard down and become less resistant to weight loss, by creating a good balance. You borrow body machinery and use it to regulate fat levels.
Side effects: there have been a lot of clinical studies on this product and Its ingredients that all showed good results and effective weight loss results. also, there have been no reports of side effects from consumers yet. The LeanBiome supplement claims to have a unique formula with zero risks, is easy to use, and guaranteed safety.
SUMMARY
It seems LeanBiome is a promising product that can help you burn fat very fast, yet stay healthy & safe. It's always best to speak with your doctor before taking a dietary supplement.
7.Helix-4
Helix-4 is a dietary supplement that claims to be able to reduce 34% of body fat in a short period. It's not only a weight loss supplement but a mood enhancer, anxiety remover, metabolism booster, and stress reliever.
It’s a capsule-form product manufactured by the NutraVille Company.
How it works: The Helix-4 will help you eliminate excess fat by using a natural process in your body. It will control the fat cells you receive by controlling the food cravings and appetite that make someone eat more than they need.
Helix-4’s power comes from a natural ingredient known as Asthisamharaka. This plant contains minerals like magnesium and calcium and antioxidants like resveratrol. Besides Asthisamharaka, Helix-4 contains three other main herbal ingredients, like ashwagandha, lemon balm, and passionflower.
The supplement also prevents the increase in blood sugar levels, which cause weight gain, by controlling the absorption of carbohydrates into fat cells.
Side effects: Its natural ingredients have been used for medicinal purposes in different cultures for several decades. Plus, this product is sugar-free, gluten-free, soy-free, and vegetarian. In comparison with those chemical metabolism boosters, surgeries, and calorie restrictions Helix-4 is a much safer choice you can have.
SUMMARY
According to user comments, The product will work much better with a healthy lifestyle and diet.
8. Burn Boost
Burn Boost is a powder supplement made by Matt Stirling, a fitness coach, and expert. This product claims it can help you burn around 200 extra calories a day without changing your diet, or anything other than simply taking the product and enjoying the results.
How it works: Burn Boost works by activating Lipolysis. Lipolysis works by converting your excess fat (Adenosine Triphosphate) into usable fat that your body can use to produce energy (cyclic adenosine monophosphate).
In addition, Burn Boost boosts your metabolism through its formula to keep your body functioning at a higher speed.
There are some well-researched ingredients in Burn Boost powder products like Coconut water powder which is proven to boost metabolism or green coffee bean extract that help your body reduce how much fat is absorbed through the digestive system.
Other key ingredients used in Burn Boosts such as glutamine and guarana, help boost your immune system to avoid getting ill while you’re losing weight or even after you have gotten the desired results.
Side effects: Burn Boost claims to have no side effects even in long-term usage because of its 100% natural and vegan ingredients. However, as with any supplement, it’s always best to speak with your doctor before taking any dietary supplement.
SUMMARY
There are a lot of compliments about Burn Boost heard from consumers. It seems that if you try it along with a healthy lifestyle, it can help you lose weight and improve your health.
9.CarboFix
Carbofix is a dietary supplement that claims to burn fats rapidly and effectively. Carbofix has made huge claims that its weight loss formula can help you lose weight, burn stored body fats, balance blood sugar, and glucose, control appetite and support a healthy immune system.
How it works: It generally works on three principles to help you lose weight and improve your health, Initiatives AMP Enzymes, Initiates Appetite Control, and Block Fat Storage.
Several studies have shown that ingredients in Carbofix have many health benefits. These ingredients help to reduce insulin resistance, blood sugar levels, and cholesterol levels in the body. They also help in weight loss by reducing the fat-storing process in the body.
The supplement uses organic herbs and extracts that have been clinically proven to give you benefits during clinical studies.
Side effects: Very satisfactory feedback from consumers as well as laboratory studies have shown that the correct use of this product is not associated with side effects.
Carbofix is formulated in a GMP facility and it also has FDA approval. It means that the formula is created under strict quality standards so you can be assured that the best is being delivered to you.
SUMMARY
Carbofix seems like a safe and effective way to help you in the process of losing weight and maintaining body health.
10. Amyl Guard
Amyl Guard is the best version of amylase inhibitor supplements that are claimed to be mixed with many other valuable ingredients to help lose weight and regulate blood sugar levels. Matraville, the manufacturer of Amyl Guard, describes this product as a “glucose disposal agent.”
How it works: According to the manufacturer, this combination can block carbs as an amylase inhibitor. Therefore, it becomes harder for the body to collect consumed carbohydrates as stored fat.
As we mentioned Amyl Guard is an amylase inhibitor, which means it shuts off an enzyme called amylase. Amylase is the enzyme responsible for breaking down carbs into sugars which later become stored as fats. The supplement can prevent this process.
As simple as it seems, it is one of the most effective ways of avoiding obesity which can not be possible otherwise unless you have an utterly carbohydrate-free diet, which is practically impossible.
Side effects: Based on many documents and studies from the Stanford Medical School, David Geffen Medical School, and Johns Hopkins University, Amyl Guard is one of the most reliable weight loss breakthroughs. Each bottle of Amyl Guard is produced at a GMP-certified FDA. It can work for everybody of all ages, genders, body figures, and any background.
SUMMARY
It's an extraordinary weight loss product. If you're already on a diet or exercising regularly, you can expect even more significant results by accompanying that with this excellent supplement.
11.MetaboFix
MetaboFix claims to be a dietary supplement that helps to boost your metabolism and reduce inflammation. The manufacturers claim that the supplement is designed for people above 40 and can help them lose weight.
How it works: MetaboFix works by boosting your metabolism. A higher metabolism means that your body will be able to burn more fat. The supplement contains natural ingredients that have been clinically proven to be effective in boosting metabolism.
MetaboFix is a breakthrough metabolism-boosting formula featuring green mango, Aronia berries, cinnamon bark, mulberry fruit, black pepper fruit extract, and over 25 other powerful ingredients.
Side effects: There are no reported side effects of MetaboFix.
The manufacturer claims that the supplement is made with all-natural ingredients and is safe to use. There are no known cases reported where the formula has affected someone medically in a bad way.
As the formula is produced in a GMP facility, the chances of it being contaminated or poorly manufactured are low. Although it might not be a bad idea to consult your doctor.
SUMMARY
If you're over 40, MetaboFix might be one of the best options to assist in your weight loss journey.
12. Exipure
Exipure is a dietary supplement used for weight loss mechanisms. The company claims that its formula can help you lose weight by initiating your brown adipose tissues that are responsible for possible weight gain.
How it works: Exipure Made this supplement based on a scientific discovery about BAT in 2022. A 2022 study published in Nature Medicine of 52,000 women and men found one important common factor in every overweight man and woman, Low brown adipose tissue levels (BAT).so Exipure targets low brown adipose tissue levels and increases it. Scientific evidence concurs BAT is a weapon against overweighting since lowering BAT levels causes body fat percentage to increase. Research has also shown that slimmer people usually have high levels of BAT.
Side effects: To this day, there have been no reports of any adverse side effects while using Exipure. As claimed It is a natural proprietary formula manufactured in the USA at FDA-registered and GMP-certified facilities using state-of-the-art, precision-engineered machinery and under the strictest and most sterile standards. Each ingredient is 100% plant-based, soy-free, dairy-free, and non-GMO. As always we advise you to show a bottle of this to your doctor before you take it, just to be safe.
SUMMARY
It is a very effective and unique weight loss supplement, especially with a healthy lifestyle.
13. Revive Daily
It's a dietary supplement that claims to be able to instantly transform your health, appearance, and quality of life by increasing GH.
How it works: A large number of valid scientific studies have shown and proved that lack of a hormone called human growth hormone or GH slows down the metabolism and leads to excess weight, stubborn belly fat, low energy, saggy skin, gray-thinning hair, and aging.
Revive Daily is made from all-natural components that have been shown in studies to have the ability to increase GH levels in the body and improve overall health.
By increasing the GH level in the body, The body's metabolism also increases, which is a very important and effective factor in burning excess fat and reducing weight.
Side effects: Revive Daily is manufactured in a facility having full FDA approval and is equally GMP-certified in the form of capsules. Additionally, the supplement is non-GMO and natural. However, there is no harm in consulting your doctor.
SUMMARY
Since countless studies have proven the effects and properties of GH, it is a valuable supplement for weight loss and your overall health that is worth trying.
Hormonal Harmony HB-5 is a hormone supplement that claims to correct five hormonal blocks of the body. The formula claims to have all-natural and effective ingredients that are sourced from the best to give the best results.
How it works: The five hormones that Hormonal Harmony HB-5 treats are thyroid, leptin, insulin, cortisol, and estrogen. Hormones and their balance play an important role in fat-burning and weight loss.
Hormonal Harmony HB-5 helps these five hormones to get in a balanced situation and strengthens their functioning.
Side effects: There is no credible evidence regarding Hormonal Harmony HB-5 side effects. The important thing is to take a consultation with your medical health care practitioner because you always need approval before starting any hormonal supplement for weight loss or other issues.
SUMMARY
Hormonal Harmony HB-5 seems to be a good hormone supplement that promises to fix five hormonal blocks leading to multiple health issues in individuals.
The bottom line
These supplements can be helpful, but the effects are modest at best.
Determining a healthy weight, focusing on mindful eating, using safe calorie deficits, and increasing your physical activity are still the best ways to lose weight, and these methods work better than all the diet pills combined.
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